I wouldn’t be against it. Especially as they’ve been better lately. But I wouldn’t be any more interested in playing Iowa state than I would be in playing Kansas state, Missouri, Colorado, Arizona (random mid tier power 5 team)Events I have been at that included Cyclone and Gopher fans have always been cordial, such as NCAA basketball tournaments (Metrodome '00 & Milwaukee '17) or long ago football/basketball games.
The shared distaste for the Hawkeyes seems to play a role in that.
Again, I am not saying create another border rivalry, just seems like they should play other at least occasionally, especially if some bucks can be made.