Not to be contradictory, but...
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BobLoblaw, post #88:
"I really worry about Bucko's abilities to break tackles on runs 15-20 in a game. I hope Bucko stays fresh (~15 carries per game). I really worry that if Bucko gets 30 and Ky gets 5, we're in serious trouble."
I equate "stays fresh" to "avoids becoming fatigued".
BobLoblaw, Post #97:
"Could it have happened to a completely fresh player? Sure. It happens all the time. But it also happens considerably more often with someone after a ton of reps."
Again, "fresh" seems to imply the lack of fatigue.
BobLoblaw, Post #106:
"When you're looking at workload, you need to look at (1) total carries; and (2) carries per game. You need to look at both of them, both of them lead to fatigue and injuries."
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So, at least on poster was proposing fatigue as a factor in injuries.