Granted, it's college football, so stupidly, absurdly, abhorrent levels of inconsistency can sprout up randomly any week. See NW.
That said, none of the current CFP top 6 ranked teams should lose a game the rest of the regular season.
Alabama will beat Florida in the SEC championship, and Clemson with Trevor will beat Notre Dame in the ACC championship.
That will put Alabama #1, Clemson #2, and Notre Dame #4 (they'll do this on purpose to avoid a 3rd game between Clemson-ND as a semi-final).
That leaves putting either Ohio State or Texas A&M as #3. SEC/ACC/ESPN can whine and cry all they like that OSU won't have qualified for the Big Ten championship ...... but neither did TA&M !! So how can you justify putting TA&M over them, when neither team lost??
Maybe I'll be wrong and OSU will play both Mich St and Mich, beat both convincingly, then go on to whip NW in the championship. That would obviously settle any doubt. Maybe even put OSU at #2 over Clemson, who knows.
Regardless, I predict that we'll have Alabama v Notre Dame in the Sugar Bowl, and Ohio State v Clemson in the Rose Bowl.