It's an interesting question and has been debated before when the Canes and SC were amazing, IIRC. Pro GMs said the best college teams of any period would get killed by a crappy NFL team, as only a small % of any college players, regardless of what team they are, get to the pros and stick there. Even if the college team has a player or two better than the NFL team, the won't have better players across the board, too many positions. Also pros are grown azz men, who only do that and don't have to worry about school etc...
Pro players have also said the biggest adjustment in the pros is that everyone is basically fast.
The coaching is also much better and the pros would kill them will matchups etc. Look at successful college coaches and how they fared in the pros -
Saban (Arguably best college coach ever) = sucked in NFL
Holtz (won at multiple schools and also a Natty) = sucked in NFL
Carroll ( won a Natty) = won a Super Bowl and lost another.
There are others, on the sucky side, like Bobby Peterino, but I ain't going that deep on a Monday evening.
To me they are 2 different strains of the same game. Shows what a great coach Pete is.