Prevent ankle sprains, no I know there not avoidable, but you can lessen there impact and likelihood of occuring with agility drills and correct blocking and footwork up front. A lot of guy's get hurt with bad footwork and lacking upper body strength. Not saying this is the case with the Gophers but you can tell, they are not able to match strength up front yet. You can't prevent getting rolled up on from behind when a guy get's knocked to the ground and rolls up on you from behind like Ed Olson had happen. Marquies got caught in a high low where the one tackler dived at his knees and twisting his leg, while the other guy hit him high as he was trying to get away twisting him up. Not really avoidable.
I was chop blocked in high school and got a high ankle sprain and dang near dislocated it as I was on crutches for 2 weeks. Strength and conditioning will matter when we start to match Juniors and Seniors against the defense,
The solution will be to play stronger Juniors and Seniors on the O-line instead of being heavy in Sophmores and red-shirt Freshman like the Gophers are now. It's year 1 and a half of the Kill program, there already having an impact as they have had enough depth to at least
withstand some of this. Mottla got rolled up and got stuck, a bad break in the leg but he was coming off an ankle sprain and needed to play because of the other guys getting hurt. They have had a run of bad luck up front, a real bad run of bad luck. Fortunately in the future they will start having the depth to overcome some of these losses.