I like to break it down into what we do well and what they do well, and then compare strengths to strengths and weaknesses to weaknesses:
Nebraska does these things well:
Running the ball (269 yards per game, #7 in the country)
Defending the pass (100.6 pass efficiency defense, #7 in the country, allow 164 yards per game, #2 in the country)
Pressuring the quarterback (2.7 sacks per games, #20 in the country)
Nebraska does not do these things well:
Passing the ball (213 yards per game, #83 in the country)
Defending the run (179.9 yards against per game, #84 in the country)
Protecting the ball (-.80 turnover margin per game, #102 in the country)
Punting (35.7 yards net per punt, #87 in the country)
Minnesota does these things well:
Defending the pass (108.8 pass efficiency defense, #16 in the country, allow 169 yards per game, #7 in the country)
Protecting the quarterback (1.5 sacks allowed per game, #38 in the country)
Minnesota does not do these things well:
Passing the ball (187.5 yards against per game, #100 in the country)
Defending the run (168 yards against per game, #73 in the country)
Punting (35.5 yards net per punt, #90 in the country)
So, their biggest offensive strength (running the ball) lines up against one of our biggest defensive weaknesses (defending the run) and one of our biggest defensive strengths (defending the pass) aligns with their biggest offensive weakness (passing the ball). Basically, it's what we all know and say, but statistically grounded.
My takeaway, I would much rather have an offensive strength to line up against their defensive weakness (as the game is often dictated by what the offense is doing). Unfortunately we don't have an offensive strength to this point in the season - both passing and running are mediocre to bad, statistically speaking, at a national level.